Next Generation of Sonoran Desert Researchers (N-Gen) represents a renewed effort to create a multinational community of investigators across disciplines. N-Gen is made up of 475+ members in 40+ disciplines across 21 regions of the Sonoran Desert. N-Gen is about our collective work and implementing the ideas we generate together. A growing sense of disconnect among fellow researchers in the same discipline, no less across an increasingly fragmented border, has made it clear that now is the time to holistically approach research and conservation in the Sonoran Desert. Dedicated to the spirit of the Sonoran Desert, the N-Gen mission is to (1) catalyze research and biocultural collaboration, (2) develop an innovative research and conservation agenda, and (3) influence decision makers in both countries to promote a conservation ethic that matches the grandeur of the landscape.